Biochemical and ultrasonographic markers in fetal surveillance

Introduction/Objective. Fetal growth restriction (FGR) is associated with increased fetal and neonatal mortality morbidity. The study objective was to investigate the correlation of maternal blood biochemical markers routinely determined in first second trimester screening ultrasound surveillance parameters prediction condition singleton pregnancies. Methods. In we measured serum levels beta subunit human chorionic gonadotropin (?HCG) pregnancy-associated plasma protein A (PAPP-A). values (HCG), alpha fetoprotein (AFP), unconjugated estriol (E3) inhibin A, also examined ultrasonographic biometric parameters, amniotic fluid index (AFI) Doppler resistance indexes. FGR defined as ultrasonographically weight below 10th percentile for gestational age. Obtained were correlated. Results. Study included 104 ?HCG correlated negatively third trimester, AFI. Increased PAPP-A positively elevated medial cerebral artery, lower biophysical profile scores, intermediate type non-stress test. Lower E3 FGR. Elevated AFP linked oligoamnion trimester. There no condition. Conclusion. First pregnancy (?HCG, PAPP-A, HCG, E3) combination fetus have predictive value development.